Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion
نویسندگان
چکیده
منابع مشابه
Comparison of the Percentages of Peripheral Blood CD4+ CD25+ T Lymphocytes in Recurrent Abortion and Normal Pregnancy
Background & Aims: Recent evidences indicate that parts of the immunoregulation system such as CD4+CD25+Tcells (Treg) and Th2 cells and Th1 cells, play very important roles in the maintenance of pregnancy. The deficiency in proper recognition of fetal alloantigen by the maternal immune system is associated with recurrent pregnancy failure. Here, we investigate the proportional changes of CD4+CD...
متن کاملThe relationship between cytokine gene polymorphism and unexplained recurrent spontaneous abortion in Saudi females.
OBJECTIVE To investigate the relationships between unexplained recurrent spontaneous abortion (RSA) and single nucleotide polymorphisms tumor necrosis factor-alpha (TNF-alpha) (-238 G/A, -308 G/A), interleukin (IL)-6 (-634 G/C) and IL-10 (-592 C/A) in the promoter region of 3 different interleukin (TNF-alpha, IL-6, and IL-10) genes. METHODS The study group comprised 65 women (mean age: 34.1+/...
متن کاملSeroprevalence of CMV and Rubella in Women with Recurrent Spontaneous Abortion in Comparison with Normal Delivery
Background & Objectives: Recurrent spontaneous abortion occurs by different etiological causes including viral infections. Cytomegalovirus and rubella infections can cause or promote the recurrent fetal loss. Cytomegalovirus is one of the important viral infections which may play a role in recurrent spontaneous abortion. Also, rubella virus infection can induce abortion especially in the first ...
متن کاملP-157: TLR5 Gene Expression in Endometrium of Women with Unexplained Recurrent Spontaneous Abortion
Background: Recurrent spontaneous abortion (RSA) is usually defined as three or more consecutive pregnancy losses before 20th week of gestation. Although different factors are considered as etiology of RSA but in some cases, despite of extensive work up, the cause of RSA remains unknown which called unexplained RSA. Immunological factors are suggested as etiological factors of unexplained RSA. ...
متن کاملComparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women
Background: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. Objective: To investigate the serum concentration of regulatory and inflammatory cytokines associated with Treg and Th...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2000
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/15.3.713